Onchocerca volvulus

Genome Assembly & Annotation

Assembly

The reference genome for Onchocerca volvulus has been produced by the Parasite Genomics group at the Wellcome Trust Sanger Institute, in collaboration with Sara Lustigman (New York Blood Center). A combination of deep sequencing and optical mapping was used on material from a single adult worm from the Republic of Cameroon.

Annotation

The gene models are actively curated by WormBase.

Downloads

• Genomic Sequence (FASTA)
• Hard-masked Genomic Sequence (FASTA)
• Soft-masked Genomic Sequence (FASTA)
• Annotations (GFF3)
• Proteins (FASTA)
• Full-length transcripts (FASTA)
• CDS transcripts (FASTA)

Tools

• Search for sequences in the genome and proteome using BLAST
• Work with lists of data using the WormBase ParaSite BioMart data-mining tool
• Programatically access WormBase ParaSite data using the REST API
• Predict the effects of variants using the Variant Effect Predictor

Key Publications

• Cotton JA, Bennuru S, Grote A, Harsha B, Tracey A, Beech R, Doyle SR, Dunn M, Hotopp JC, Holroyd N, Kikuchi T, Lambert O, Mhashilkar A, Mutowo P, Nursimulu N, Ribeiro JM, Rogers MB, Stanley E, Swapna LS, Tsai IJ, Unnasch TR, Voronin D, Parkinson J, Nutman TB, Ghedin E, Berriman M, Lustigman S. The genome of Onchocerca volvulus, agent of river blindness. Nat Microbiol, 2016;2():16216

Resources

\n* The CDC Foundation helps the Center for Disease Control and Prevention

\n* The World Health Organisation

\n* Filariasis Research Reagent Resource Center (FR3)

Navigation

View karyotype

Genome Browser (JBrowse)

Genome Browser (Ensembl)

Example gene page

Example gene tree

Gene Expression