Angiostrongylus cantonensis

BioProject PRJEB493 | Data Source Wellcome Sanger Institute | Taxonomy ID 6313

About Angiostrongylus cantonensis

The nematode Angiostrongylus cantonensis, or rat lungworm, is the most common cause of human eosinophilic meningitis. Humans are incidental hosts that become infected through ingestion of raw or undercooked infected rats (definitive host), snails, slugs, crabs, freshwater shrimps, or vegetables contaminated by slime from or parts of infected snails and slugs.

There is 1 alternative genome project for Angiostrongylus cantonensis available in WormBase ParaSite: PRJNA350391

Genome Assembly & Annotation

Assembly

The draft genome assembly was produced by the Parasite Genomic group at the Wellcome Trust Sanger Institute, in collaboration with Lian-Chen Wang (Chang Gung University, Taiwan) as part of the 50 Helminth Genomes project. The assembly uses Illumina paired-end sequencing followed by an in-house genome assembly pipeline comprising various steps, including contig assembly, scaffolding, gap-filling and error-correction.

Annotation

The gene predictions were made by the Parasite Genomics group at the Wellcome Trust Sanger Institute and WormBase, as part of the 50 Helminth Genomes project. An in-house pipeline was developed that used MAKER to generate high-quality annotations by integrating evidence from multiple sources: ab initio gene predictions from AUGUSTUS, GeneMark-ES, and SNAP; projected annotation from C. elegans (using GenBlastG) and the taxonomically nearest reference helminth genome (using RATT); and ESTs, mRNAs and proteins from related organisms aligned to the genome using BLAST, with refinement of alignments using Exonerate.

Key Publications

Assembly Statistics

AssemblyA_cantonensis_Taipei_v1_5_4, GCA_000950995.1
StrainRepublic of China
Database VersionWBPS18
Genome Size253,242,791
Data SourceWellcome Sanger Institute
Annotation Version2014-06-50HGPpatch

Gene counts

Coding genes14,520
Gene transcripts14,520

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